NCT07641517
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
Sponsored by Eli Lilly and Company
The main purpose of this study is to test the safety and efficacy of study drug for the treatment of knee pain due to osteoarthritis (OA). This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292), which is a protocol to accelerate the development of new treatments for chronic pain.
Inclusion Criteria: * Have presence of index knee pain for more than 12 weeks at screening * Have an x-ray supporting diagnosis of osteoarthritis according to the American College of Rheumatology with a Kellgren-Lawrence grade 2 to 4 radiographic classification of index knee * Have a body mass index ≤40 kilograms per meter squared (kg/m²) (inclusive) * Have stable glycemic control as indicated by a glycated hemoglobin (HbA1c) less than or equal to 10 at time of screening Exclusion Criteria: * Are pregnant or breastfeeding * Have had a surgical procedure or therapeutic injection in the affected knee within 3 months prior to screening * Have presence of surgical hardware or other foreign body in the index knee * Have ongoing complex regional pain syndrome or other concurrent medical condition that could interfere with the evaluation of pain in the index knee. * Have had any joint replacement of the lower extremity, such as hip, knee or ankle, in the 6 months prior to screening * Have an abnormal blood pressure (BP) (systolic BP greater than 140 millimeters mercury (\>140 mm Hg) and diastolic BP\>90 mm Hg) at screening * Have history or current clinically significant cardiac disease, including arrhythmia, aortic aneurysm, heart failure, current electrolyte abnormalities, or any other conditions that could predispose to arrhythmia in the judgement of the investigator
Central Research Associates
Birmingham, Alabama, United States
Synexus Clinical Research US, Inc.
Phoenix, Arizona, United States
Arizona Research Center
Phoenix, Arizona, United States
Desert Oasis Healthcare Medical Group
Palm Springs, California, United States
Artemis Institute for Clinical Research
Riverside, California, United States
Artemis Institute for Clinical Research
San Diego, California, United States
CMR of Greater New Haven
Hamden, Connecticut, United States
Bradenton Research Center, Inc.
Bradenton, Florida, United States
Accel Research Sites - DeLand Clinical Research Unit
DeLand, Florida, United States
K2 MEDICAL Research THE VILLAGES
Lady Lake, Florida, United States
K2 Medical Research ORLANDO
Maitland, Florida, United States
Merritt Island Medical Research, LLC
Merritt Island, Florida, United States
Suncoast Research Group
Miami, Florida, United States
New Horizon Research Center
Miami, Florida, United States
Suncoast Clinical Research, Inc.
New Port Richey, Florida, United States
Renstar Medical Research
Ocala, Florida, United States
Precision Clinical Research
Sunrise, Florida, United States
Charter Research - Lady Lake
The Villages, Florida, United States
Conquest Research
Winter Park, Florida, United States
North Georgia Clinical Research
Woodstock, Georgia, United States
Northwestern University
Chicago, Illinois, United States
DelRicht Research
New Orleans, Louisiana, United States
Lucida Clinical Trials
New Bedford, Massachusetts, United States
MedVadis Research Corporation
Waltham, Massachusetts, United States
Great Lakes Research Group, Inc.
Bay City, Michigan, United States
StudyMetrix Research
City of Saint Peters, Missouri, United States
Clinvest Research LLC
Springfield, Missouri, United States
Rochester Clinical Research, LLC
Rochester, New York, United States
Lillestol Research
Fargo, North Dakota, United States
META Medical Research Institute
Dayton, Ohio, United States
DelRicht Research
Tulsa, Oklahoma, United States
Altoona Center For Clinical Research
Duncansville, Pennsylvania, United States
FutureSearch Trials of Neurology
Austin, Texas, United States
Re:Cognition Health - Fort Worth
Fort Worth, Texas, United States
Northwest Clinical Research Center
Bellevue, Washington, United States
Rainier Clinical Research Center
Renton, Washington, United States
Ponce Medical School Foundation Inc.
Ponce, Puerto Rico
Identity-resolution confidence concerns registry/entity resolution and does not determine clinical eligibility.
Interested in this trial?
Express your interest and we'll connect you with the trial team.
Your selected profile and contact information may be shared with an authorised trial site, sponsor, or Clintriva coordination team for trial contact and pre-screening. Expressing interest does not mean you are eligible or enrolled.
Conditions